Consortium of Swiss Academic Libraries

GLUT2, glucose sensing and glucose homeostasis

Thorens, Bernard

In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232

Université de Fribourg

Myosin 1b regulates nuclear AKT activation by preventing localization of PTEN in the nucleus

Yu, Yi ; Xiong, Yuyan ; Ladeiras, Diogo ; Yang, Zhihong ; Ming, Xiu-Fen

In: iScience, 2019, vol. 19, p. 39–53

Insulin-induced AKT activation is dependent on phosphoinositide 3-kinase and opposed by tumor suppressor phosphatase and tensin homolog (PTEN). Our previous study demonstrates that myosin 1b (MYO1B) mediates arginase-II-induced activation of mechanistic target of rapamycin complex 1 that is regulated by AKT. However, the role of MYO1B in AKT activation is unknown. Here we show that silencing...