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Insulin secretion response during oral glucose tolerance test is related to low cardiorespiratory fitness in obese adolescents

Maggio, Albane B.R. ; Bou Puigdefabregas, Julie Wacker ; Schwitzgebel, Valerie M. ; Chamay-Weber, Catherine ; Beghetti, Maurice ; Farpour-Lambert, Nathalie J.

In: Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 5-6, p. 539-544

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    Titre
    • Insulin secretion response during oral glucose tolerance test is related to low cardiorespiratory fitness in obese adolescents
    Auteur
    • Maggio, Albane B.R.. Pediatric Obesity and Chronic Diseases, Service of Pediatric Specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, 1211 Geneva 14, Switzerland
    • Bou Puigdefabregas, Julie Wacker. Pediatric Cardiology Unit, Service of Pediatric Specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, 1211 Geneva 14, Switzerland
    • Schwitzgebel, Valerie M.. Pediatric Endocrine and Diabetes Unit, Division of Growth and Development, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, 1211 Geneva 14, Switzerland
    • Chamay-Weber, Catherine. Pediatric Obesity and Chronic Diseases, Service of Pediatric Specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, 1211 Geneva 14, Switzerland
    • Beghetti, Maurice. Pediatric Cardiology Unit, Service of Pediatric Specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, 1211 Geneva 14, Switzerland
    • Farpour-Lambert, Nathalie J.
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 5-6, p. 539-544. De Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:326113
    Summary
    Background: The obesity paradox refers to a category of subjects who may be less prone to develop co-morbidities, such as type 2 diabetes. Cardiorespiratory fitness (CRF) has been identified as one of the key factors. We aimed at exploring the difference in insulin metabolism between fit and unfit obese adolescents. Methods: We recruited 22 obese adolescents and assessed CRF during an incremental treadmill test. According to a cut-off at 80% of predicted maximal oxygen consumption (VO2max), subjects were separated into low or normal CRF. Body composition was determined by densitometry. Serum levels of insulin were measured sequentially during an oral glucose tolerance test and insulin secretion responses were calculated. Results: Compared to adolescents with normal CRF, the ones with low CRF had higher insulin resistance indices (p=0.023) and insulin secretion response (p=0.010), independently of the body mass index z-score. Conclusions: Interventions in obese adolescents should focus on the maintenance or improvement of CRF to at least 80% of predicted VO2max. Indeed, this cut-off was significantly related to insulin secretion responses, independently of the adiposity level. A CRF above the proposed cut-off may prevent the development of insulin resistance.