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Decreasing Insulin Sensitivity in Women Induces Alterations in LH Pulsatility

van Leckwyck, Magali ; Kong, Weilin ; Burton, Kathryn J. ; Amati, Francesca ; Vionnet, Nathalie ; Pralong, François P.

In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 8, p. 3240-3249

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    Titre
    • Decreasing Insulin Sensitivity in Women Induces Alterations in LH Pulsatility
    Auteur
    • van Leckwyck, Magali. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    • Kong, Weilin. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    • Burton, Kathryn J.. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    • Amati, Francesca. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    • Vionnet, Nathalie. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    • Pralong, François P.. Service of Endocrinology, Diabetology, and Metabolism (M.v.L., W.K., K.J.B., F.A., N.V., F.P.P.), Lausanne University Hospital, 1011 Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 8, p. 3240-3249. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332680
    Summary
    Context: Obesity is associated with neuroendocrine reproductive alterations and decreased fertility. Objective: The objective of the study was to gain insight into the neuroendocrine mechanisms implicated in these alterations. Design: The effects on pulsatile LH secretion of 28 days of a hypercaloric diet were studied in lean and regularly cycling female volunteers. Approximately 50% extra calories (3 g sucrose/kg body weight per day and 1 g fat/kg body weight per day) were added to their individual daily requirements. Spontaneous and insulin-stimulated LH secretion was recorded on 2 different days, before and at the end of the caloric load. Results: The hypercaloric diet induced an average weight gain of 2.0 ± 0.3 kg (P < .05), corresponding to a body mass index increase of 0.7 ± 0.1 kg/m2 (P < .05). A concomitant decrease of 11.6% ± 4.6% in whole-body insulin sensitivity was also observed (δ = −1.6 ± 0.7 mg/kg · min glucose; P < .05). The frequency of spontaneous and insulin-stimulated pulsatile LH secretion was increased by 17.9% ± 9.0% and 26.5% ± 9.0%, respectively (both P < .05). Spontaneous LH peak amplitude was decreased by 26.5% ± 9.0% (δ = −0.7 ± 0.36 U/L; P < .05), a change correlated with insulin sensitivity. Conclusions: Short-term weight gain in normal female volunteers induces alterations of LH secretion reminiscent to those observed in obesity. A decrease in insulin sensitivity may constitute a mechanistic link between obesity and its associated neuroendocrine dysfunctions.