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Université de Fribourg

Ex vivo analysis of kidney graft viability using 31p magnetic resonance imaging spectroscopy

Longchamp, Alban ; Klauser, Antoine ; Songeon, Julien ; Agius, Thomas ; Nastasi, Antonio ; Ruttiman, Raphael ; Moll, Solange ; Meier, Raphael P. H. ; Buhler, Leo ; Corpataux, Jean-Marc ; Lazeyras, Francois

In: Transplantation, 2020, vol. 104, no. 9, p. 1825–1831

Background: The lack of organs for kidney transplantation is a growing concern. Expansion in organ supply has been proposed through the use of organs after circulatory death (donation after circulatory death [DCD]). However, many DCD grafts are discarded because of long warm ischemia times, and the absence of reliable measure of kidney viability. 31P magnetic resonance imaging (pMRI)...

Université de Fribourg

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...

Université de Fribourg

Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis

Merz, Tamara ; Wepler, Martin ; Nußbaum, Benedikt ; Vogt, Josef ; Calzia, Enrico ; Wang, Rui ; Szabo, Csaba ; Radermacher, Peter ; McCook, Oscar

In: Intensive Care Medicine Experimental, 2018, vol. 6, no. 1, p. 43

Sepsis is associated with disturbed glucose metabolism and reduced mitochondrial activity and biogenesis, ultimately leading to multiple organ dysfunction, e.g., acute kidney injury (AKI). Cystathionine-γ-lyase (CSE), the major cardiovascular source of endogenous H2S release, is implicated in the regulation of glucose metabolism and mitochondrial activity through a PGC1α-dependent...