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Plasma levels of endothelin-1 and renal function among young and healthy adults

Fischer, Andreas ; Bossard, Matthias ; Aeschbacher, Stefanie ; Egli, Peter ; Cordewener, Carolin ; Estis, Joel ; Todd, John ; Risch, Martin ; Risch, Lorenz ; Conen, David

In: Clinical Chemistry and Laboratory Medicine (CCLM), 2017, vol. 55, no. 8, p. 1202-1208

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    Titre
    • Plasma levels of endothelin-1 and renal function among young and healthy adults
    Auteur
    • Fischer, Andreas. Cardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland
    • Bossard, Matthias. Cardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland
    • Aeschbacher, Stefanie. Cardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland
    • Egli, Peter. Cardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland
    • Cordewener, Carolin. Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland
    • Estis, Joel. Singulex, Inc., Clinical Research, Alameda, CA, USA
    • Todd, John. Singulex, Inc., Clinical Research, Alameda, CA, USA
    • Risch, Martin. Labormedizinisches Zentrum Dr. Risch, Schaan, Principality of Liechtenstein
    • Risch, Lorenz. Labormedizinisches Zentrum Dr. Risch, Schaan, Principality of Liechtenstein
    • Conen, David. Cardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Clinical Chemistry and Laboratory Medicine (CCLM), 2017, vol. 55, no. 8, p. 1202-1208. De Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331451
    Summary
    AbstractBackground: Endothelin-1 (ET-1), a vasoconstrictive and pro-inflammatory peptide, is associated with several cardiovascular risk factors and outcomes. We aimed to investigate the association of plasma ET-1 levels and renal function among young and healthy adults. Methods: Individuals aged 25-41 years were enrolled in a population-based cohort study. Main exclusion criteria were established kidney disease, cardiovascular diseases, diabetes mellitus and a body mass index>35 kg/m2. Fasting venous plasma samples were used to measure creatinine, cystatin C and ET-1. The estimated glomerular filtration rate (eGFR) was calculated using the creatinine based chronic kidney disease epidemiology collaboration (CKD-EPI) formula. Multivariable regression models were constructed to assess interrelationships of plasma ET-1 with parameters of renal function. Results: Median age of the 2139 participants was 37 years, 47% males. Median creatinine and eGFR were 67 μmol/L and 112 mL/min/1.73 m2, respectively. Using quartile one as the reference group, the β-coefficients (95% confidence intervals [CIs]) for eGFR were 0.06 (− 1.22 to 1.35),−0.66 (− 1.95 to 0.62) and−1.70 (− 3.01 to−0.39) for quartiles 2-4 (p-for-trend=0.0056), respectively and β-coefficients (95% CIs) for cystatin C were 0.002 (− 0.01 to 0.02), 0.02 (0.003-0.03) and 0.03 (0.01-0.04) for quartiles 2-4 (p-for-trend<0.0001), respectively. Using ET-1 as a continuous variable, the β-coefficient (95% CI) for eGFR per 1-unit increase was−1.82 (− 3.19 to−0.44, p=0.0095) and 0.02 (0.01-0.04, p=0.0003) for cystatin C. Similar results were found between creatinine and ET-1 levels. Conclusions: ET-1 levels are strongly associated with parameters of renal function among young and healthy adults, suggesting an important role of ET-1 and endothelial function in the regulation of kidney function.