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Université de Fribourg

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...

Università della Svizzera italiana

Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation

Bernasconi, Riccardo ; Soldà, Tatiana ; Galli, Carmela ; Pertel, Thomas ; Luban, Jeremy ; Molinari, Maurizio

In: Plos one, 2010, vol. 5, no. 9, p. e13008

Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments. Surprisingly, however, no data is available on the involvement of endoplasmic reticulum (ER)-resident members of the PPI family in protein folding, quality control or...