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Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort

Koller, Michael ; van Delden, Christian ; Müller, Nicolas ; Baumann, Philippe ; Lovis, Christian ; Marti, Hans-Peter ; Fehr, Thomas ; Binet, Isabelle ; De Geest, Sabina ; Bucher, Heiner ; Meylan, Pascal ; Pascual, Manuel ; Steiger, Jürg

In: European Journal of Epidemiology, 2013, vol. 28, no. 4, p. 347-355

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    Titre
    • Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort
    Auteur
    • Koller, Michael. Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    • van Delden, Christian. Service of Transplantation, Department of Surgery, University Hospitals Geneva, University of Geneva, Geneva, Switzerland
    • Müller, Nicolas. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    • Baumann, Philippe. Division of Medical Information Sciences, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
    • Lovis, Christian. Division of Medical Information Sciences, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
    • Marti, Hans-Peter. Department of Nephrology and Hypertension, Inselspital, University of Bern, Bern, Switzerland
    • Fehr, Thomas. Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    • Binet, Isabelle. Nephrology/Transplantation Medicine, Kantonsspital, St. Gallen, Switzerland
    • De Geest, Sabina. Institute of Nursing Science, University of Basel, Basel, Switzerland
    • Bucher, Heiner. Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    • Meylan, Pascal. Institute of Microbiology and Infectious Diseases Service, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    • Pascual, Manuel. Transplantation Centre, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    • Steiger, Jürg. Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Epidemiology, 2013, vol. 28, no. 4, p. 347-355. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321150
    Summary
    In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10% of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine