Fulltext

The Swiss Transplant Cohort Study: Lessons from the First 6Years

Berger, Christoph ; Bochud, Pierre-Yves ; Boggian, Katja ; Cusini, Alexia ; Egli, Adrian ; Garzoni, Christian ; Hirsch, Hans ; Hoffmann, Matthias ; Khanna, Nina ; Manuel, Oriol ; Meylan, Pascal ; Nadal, David ; van Delden, Christian ; Weisser, Maja ; Mueller, Nicolas

In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5

Ajouter à la liste personnelle
    Titre
    • The Swiss Transplant Cohort Study: Lessons from the First 6Years
    Auteur
    • Berger, Christoph. Division of Infectious Diseases and Hospital Epidemiology and Children's Research Center, University Children's Hospital of Zürich, Zürich, Switzerland
    • Bochud, Pierre-Yves. Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland
    • Boggian, Katja. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
    • Cusini, Alexia. University Clinic for Infectious Diseases, University Hospital Bern, Bern, Switzerland
    • Egli, Adrian. Clinical Microbiology, University Hospital Basel, Basel, Switzerland
    • Garzoni, Christian. University Clinic for Infectious Diseases, University Hospital Bern, Bern, Switzerland
    • Hirsch, Hans. Transplantation & Clinical Virology Division, Department Biomedicine, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    • Hoffmann, Matthias. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
    • Khanna, Nina. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    • Manuel, Oriol. Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland
    • Meylan, Pascal. Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland
    • Nadal, David. Division of Infectious Diseases and Hospital Epidemiology and Children's Research Center, University Children's Hospital of Zürich, Zürich, Switzerland
    • van Delden, Christian. Service of Transplantation, Department of Surgery, University Hospitals Geneva, University of Geneva, Geneva, Switzerland
    • Weisser, Maja. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    • Mueller, Nicolas. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100/ RAE U 70, 8091, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331510
    Summary
    Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95% of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.