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Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence

Schneider, J. ; Il'yasov, K. ; Hennig, J. ; Martin, E.

In: Neuroradiology, 2004, vol. 46, no. 4, p. 258-266

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    Titre
    • Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence
    Auteur
    • Schneider, J.. Department of Neuroradiology and Magnetic Resonance Imaging, University Children's Hospital, Steinwiesstrasse 75, 8032, Zürich, Switzerland
    • Il'yasov, K.. Department of Diagnostic Radiology, Section of Medical Physics, University Medical Centre, Hugstetter Strasse 55, 79106, Freiburg, Germany
    • Hennig, J.. Department of Diagnostic Radiology, Section of Medical Physics, University Medical Centre, Hugstetter Strasse 55, 79106, Freiburg, Germany
    • Martin, E.. Department of Neuroradiology and Magnetic Resonance Imaging, University Children's Hospital, Steinwiesstrasse 75, 8032, Zürich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317313
    Summary
    We investigated the isotropic diffusion coefficient (D') and fractional anisotropy (FA) in white matter (WM) during brain development, using an optimised diffusion-tensor imaging (DTI) method with whole brain coverage in a clinically acceptable time. We images 52children with no evident neurological abnormality (30boys, 22girls aged 1day-16years) using high-angle DTI with optimised temporal gradient performance. D' and FA were calculated in 10regions of interest in white matter. We saw that the age-related reduction in D' and increase in FA follow a mono- or biexponential model in white matter, probably depending on the compactness and myelination rate of the fibre tracts. In contrast to other areas, in which adult values were reached during the third year, there is a trend to continuous increase in FA in all deep white-matter areas, suggesting continuing maturation and organisation of deep tracts not detected on conventional MRI