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The renal type IIa Na/Pi cotransporter : Structure-function relationships

Murer, Heini ; Köhler, Katja ; Lambert, Georg ; Stange, Gerti ; Biber, Jürg ; Forster, Ian

In: Cell Biochemistry and Biophysics, 2002, vol. 36, no. 2-3, p. 215-220

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    Titre
    • The renal type IIa Na/Pi cotransporter
      Structure-function relationships
    Auteur
    • Murer, Heini. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    • Köhler, Katja. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    • Lambert, Georg. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    • Stange, Gerti. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    • Biber, Jürg. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    • Forster, Ian. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cell Biochemistry and Biophysics, 2002, vol. 36, no. 2-3, p. 215-220. Humana Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313044
    Summary
    The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling (1-4). In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein ("molecular domains”) that potentially determine transport characteristics