Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
Bellone, C. ; Lüscher, C. ; Mameli, M.
In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 18, p. 2913-2923
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- Abstract.: Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity