Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

Bellone, C. ; Lüscher, C. ; Mameli, M.

In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 18, p. 2913-2923

Aggiungi alla tua lista
    Summary
    Abstract.: Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity