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Immunoglobulin Attenuates Streptokinase-Mediated Virulence inStreptococcus dysgalactiae Subspeciesequisimilis Necrotizing Fasciitis

Andreoni, Federica ; Ugolini, Fabio ; Keller, Nadia ; Neff, Andrina ; Nizet, Victor ; Hollands, Andrew ; Marques Maggio, Ewerton ; Zinkernagel, Annelies S. ; Schuepbach, Reto A.

In: The Journal of Infectious Diseases, 2018, vol. 217, no. 2, p. 270-279

Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study

Kusejko, Katharina ; Kadelka, Claus ; Marzel, Alex ; Battegay, Manuel ; Bernasconi, Enos ; Calmy, Alexandra ; Cavassini, Matthias ; Hoffmann, Matthias ; Böni, Jürg ; Yerly, Sabine ; Klimkait, Thomas ; Perreau, Matthieu ; Rauch, Andri ; Günthard, Huldrych F. ; Kouyos, Roger D. ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover

In: Virus Evolution, 2018, vol. 4, no. 2, p. -

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François, Patrice ; von Dach, Elodie ; Diene, Seydina M. ; Harbarth, Stephan ; Schrenzel, Jacques

In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1610-1611

The Swiss Transplant Cohort Study: Lessons from the First 6Years

Berger, Christoph ; Bochud, Pierre-Yves ; Boggian, Katja ; Cusini, Alexia ; Egli, Adrian ; Garzoni, Christian ; Hirsch, Hans ; Hoffmann, Matthias ; Khanna, Nina ; Manuel, Oriol ; Meylan, Pascal ; Nadal, David ; van Delden, Christian ; Weisser, Maja ; Mueller, Nicolas

In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5

Swiss consensus recommendations on urinary tract infections in children

Buettcher, Michael ; Trueck, Johannes ; Niederer-Loher, Anita ; Heininger, Ulrich ; Agyeman, Philipp ; Asner, Sandra ; Berger, Christoph ; Bielicki, Julia ; Kahlert, Christian ; Kottanattu, Lisa ; Meyer Sauteur, Patrick M. ; Paioni, Paolo ; Posfay-Barbe, Klara ; Relly, Christa ; Ritz, Nicole ; Zimmermann, Petra ; Zucol, Franziska ; Gobet, Rita ; Shavit, Sandra ; Rudin, Christoph ; Laube, Guido ; von Vigier, Rodo ; Neuhaus, Thomas J.

In: European Journal of Pediatrics, 2020, p. -

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. The differentiation between...

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...

Large-scale analysis of the mycoplasma bovis genome identified non-essential, adhesion- and virulence-related genes

Josi, Christoph ; Bürki, Sibylle ; Vidal, Sara ; Dordet-Frisoni, Emilie ; Citti, Christine ; Falquet, Laurent ; Pilo, Paola

In: Frontiers in Microbiology, 2019, vol. 10, p. -

Mycoplasma bovis is an important pathogen of cattle causing bovine mycoplasmosis. Clinical manifestations are numerous, but pneumonia, mastitis, and arthritis cases are mainly reported. Currently, no efficient vaccine is available and antibiotic treatments are not always satisfactory. The design of new, efficient prophylactic and therapeutic approaches requires a better understanding of the...

Serum immunoglobulin a cross-strain blockade of human noroviruses

Lindesmith, Lisa C. ; Beltramello, Martina ; Swanstrom, Jesica ; Jones, Taylor A. ; Corti, Davide ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Open forum infectious diseases, 2015, vol. 2, no. 3, p. ofv084

Background: Human noroviruses are the leading cause of acute viral gastroenteritis, justifying vaccine development despite a limited understanding of strain immunity. After genogroup I (GI).1 norovirus infection and immunization, blockade antibody titers to multiple virus-like particles (VLPs) increase, suggesting that GI cross-protection may occur. Methods: Immunoglobulin (Ig)A was purified...

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C

Gómez, Carmen Elena ; Perdiguero, Beatriz ; Jiménez, Victoria ; Filali-Mouhim, Abdelali ; Ghneim, Khader ; Haddad, Elias K. ; Quakkerlaar, Esther D. ; Delaloye, Julie ; Harari, Alexandre ; Roger, Thierry ; Dunhen, Thomas ; Sékaly, Rafick P. ; Melief, Cornelis J. M. ; Calandra, Thierry ; Sallusto, Federica ; Lanzavecchia, Antonio ; Wagner, Ralf ; Pantaleo, Giuseppe ; Esteban, Mariano

In: Plos one, 2012, vol. 7, no. 4, p. e35485

Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing the HIV-1...