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Immunoglobulin Attenuates Streptokinase-Mediated Virulence inStreptococcus dysgalactiae Subspeciesequisimilis Necrotizing Fasciitis

Andreoni, Federica ; Ugolini, Fabio ; Keller, Nadia ; Neff, Andrina ; Nizet, Victor ; Hollands, Andrew ; Marques Maggio, Ewerton ; Zinkernagel, Annelies S. ; Schuepbach, Reto A.

In: The Journal of Infectious Diseases, 2018, vol. 217, no. 2, p. 270-279

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    Titre
    • Immunoglobulin Attenuates Streptokinase-Mediated Virulence inStreptococcus dysgalactiae Subspeciesequisimilis Necrotizing Fasciitis
    Auteur
    • Andreoni, Federica. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Ugolini, Fabio. Institute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Switzerland
    • Keller, Nadia. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Neff, Andrina. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Nizet, Victor. Department of Pediatrics, Division of Pharmacology and Drug Discovery, San Diego, California
    • Hollands, Andrew. Department of Pediatrics, Division of Pharmacology and Drug Discovery, San Diego, California
    • Marques Maggio, Ewerton. Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Switzerland
    • Zinkernagel, Annelies S.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Schuepbach, Reto A.. Institute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2018, vol. 217, no. 2, p. 270-279. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332224
    Summary
    A clinicalStreptococcus dysgalactiae equisimilis strain secreting high levels of streptokinase promoted severe disease in a patient lacking anti-streptokinase antibodies. Exogenous immunoglobulins efficiently blocked streptokinase-mediated fibrinolysis in vitro and attenuated streptokinase-mediated virulence in a necrotizing fasciitis mouse model.