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Università della Svizzera italiana

Prevalence of physiological uptake in the pancreas on somatostatin receptor-based PET/CT : a systematic review and a meta-analysis

Boughdad, Sarah ; Meyer, Marie ; Prior, John O. ; Fernandes, Victor ; Allenbach, Gilles ; Kamani, Christel ; Jreige, Mario ; Albano, Domenico ; Bertagna, Francesco ; Nicod-Lalonde, Marie ; Schaefer, Niklaus ; Treglia, Giorgio

In: Clinical and Translational Imaging, 2021, vol. 9, no. 4, p. 353–360

Background: Physiological focal radiopharmaceutical uptake in the head and uncinate process of the pancreas may be seen on somatostatin receptor-based PET/CT and might lead to false-positive results for neuroendocrine tumours (NETs). We aimed to perform a systematic review and a meta-analysis about the prevalence of this finding. Methods: We performed a comprehensive computer literature search...

Consortium of Swiss Academic Libraries

Sarcoma of the heart: survival after surgery

Niclauss, Lars ; Montemurro, Michael ; Kirsch, Matthias ; Prêtre, René

In: Interactive CardioVascular and Thoracic Surgery, 2018, vol. 27, no. 2, p. 198-201

Consortium of Swiss Academic Libraries

Towards tailored radiopeptide therapy

Radojewski, Piotr ; Dumont, Rebecca ; Marincek, Nicolas ; Brunner, Philippe ; Mäcke, Helmut ; Müller-Brand, Jan ; Briel, Matthias ; Walter, Martin

In: European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 8, p. 1231-1237

Università della Svizzera italiana

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Revandkar, Ajinkya ; Perciato, Maria Luna ; Toso, Alberto ; Alajati, Abdullah ; Chen, Jingjing ; Gerber, Hermeto ; Dimitrov, Mitko ; Rinaldi, Andrea ; Delaleu, Nicolas ; Pasquini, Emiliano ; D’Antuono, Rocco ; Pinton, Sandra ; Losa, Marco ; Gnetti, Letizia ; Arribas, Alberto ; Fraering, Patrick ; Bertoni, Francesco ; Nepveu, Alain ; Andrea Alimonti

In: Nature communications, 2016, vol. 7, p. 13719

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of the therapeutic efficacy of NOTCH inhibitors in prostate cancer is lacking. Here, we provide evidence that PTEN loss in prostate tumours ...

Università della Svizzera italiana

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Pickett, Julie E. ; Thompson, John M. ; Sadowska, Agnieszka ; Tkaczyk, Christine ; Sellman, Bret R. ; Minola, Andrea ; Corti, Davide ; Lanzavecchia, Antonio ; Miller, Lloyd S. ; Thorek, Daniel LJ

In: Bone research, 2018, vol. 6, p. 13

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in...