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PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison

Queiroz, Marcelo ; Kubik-Huch, Rahel ; Hauser, Nik ; Freiwald-Chilla, Bianka ; von Schulthess, Gustav ; Froehlich, Johannes ; Veit-Haibach, Patrick

In: European Radiology, 2015, vol. 25, no. 8, p. 2222-2230

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    Titre
    • PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison
    Auteur
    • Queiroz, Marcelo. Department Medical Radiology, Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    • Kubik-Huch, Rahel. Department of Radiology, Kantonsspital Baden AG, Baden, Switzerland
    • Hauser, Nik. Department of Gynaecology, Kantonsspital Baden AG, Baden, Switzerland
    • Freiwald-Chilla, Bianka. Department of Radiology, Kantonsspital Baden AG, Baden, Switzerland
    • von Schulthess, Gustav. Department Medical Radiology, Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    • Froehlich, Johannes. Guerbet AG, Zurich, Switzerland
    • Veit-Haibach, Patrick. Department Medical Radiology, Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • European Radiology, 2015, vol. 25, no. 8, p. 2222-2230. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332903
    Summary
    Purpose: To compare the diagnostic accuracy of PET/MRI and PET/CT for staging and re-staging advanced gynaecological cancer patients as well as identify the potential benefits of each method in such a population. Material and methods: Twenty-six patients with suspicious or proven advanced gynaecological cancer (12 ovarian, seven cervical, one vulvar and four endometrial tumours, one uterine metastasis, and one primary peritoneal cancer) underwent whole-body imaging with a sequential trimodality PET/CT/MR system. Images were analysed regarding primary tumour detection and delineation, loco-regional lymph node staging, and abdominal/extra-abdominal distant metastasis detection (last only by PET/CT). Results: Eighteen (69.2%) patients underwent PET/MRI for primary staging and eight patients (30.8%) for re-staging their gynaecological malignancies. For primary tumour delineation, PET/MRI accuracy was statistically superior to PET/CT (p < 0.001). Among the different types of cancer, PET/MRI presented better tumour delineation mainly for cervical (6/7) and endometrial (2/3) cancers. PET/MRI for local evaluation as well as PET/CT for extra-abdominal metastases had therapeutic consequences in three and one patients, respectively. PET/CT detected 12 extra-abdominal distant metastases in 26 patients. Conclusion: PET/MRI is superior to PET/CT for primary tumour delineation. No differences were found in detection of regional lymph node involvement and abdominal metastases detection. Key Points : • PET/MRI is superior to PET/CT for primary tumour delineation • PET/CT represents a reliable tool to detect extra-abdominal distant metastasis • PET/MRI might be the preferred imaging modality for staging cervical and endometrial tumours • Whole-body staging for detection and evaluation of extra-abdominal metastases is mandatory