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Université de Fribourg

Inference of natural selection from ancient DNA

Dehasque, Marianne ; Ávila‐Arcos, María C. ; Díez‐del‐Molino, David ; Fumagalli, Matteo ; Guschanski, Katerina ; Lorenzen, Eline D. ; Malaspinas, Anna‐Sapfo ; Marques‐Bonet, Tomas ; Martin, Michael D. ; Murray, Gemma G. R. ; Papadopulos, Alexander S. T. ; Therkildsen, Nina Overgaard ; Wegmann, Daniel ; Dalén, Love ; Foote, Andrew D.

In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108

Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...

Université de Fribourg

Computational socioeconomics

Gao, Jian ; Zhang, Yi-Cheng ; Zhou, Tao

In: Physics Reports, 2019, vol. 817, p. 1–104

Uncovering the structure of socioeconomic systems and timely estimation of socioeconomic status are significant for economic development. The understanding of socioeconomic processes provides foundations to quantify global economic development, to map regional industrial structure, and to infer individual socioeconomic status. In this review, we will make a brief manifesto about a new ...

Université de Fribourg

Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity

Rus, Florentina ; Flatt, Thomas ; Tong, Mei ; Aggarwal, Kamna ; Okuda, Kendi ; Kleino, Anni ; Yates, Elisabeth ; Tatar, Marc ; Silverman, Neal

In: The EMBO Journal, 2013, vol. 32, no. 11, p. 1626–1638

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial...

Université de Fribourg

Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria

Veeramah, Krishna R. ; Rott, Andreas ; Groß, Melanie ; Dorp, Lucy van ; López, Saioa ; Kirsanow, Karola ; Sell, Christian ; Blöcher, Jens ; Wegmann, Daniel ; Link, Vivian ; Hofmanová, Zuzana ; Peters, Joris ; Trautmann, Bernd ; Gairhos, Anja ; Haberstroh, Jochen ; Päffgen, Bernd ; Hellenthal, Garrett ; Haas-Gebhard, Brigitte ; Harbeck, Michaela ; Burger, Joachim

In: Proceedings of the National Academy of Sciences, 2018, p. 201719880

Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demographic processes occurring during the intervening periods have been absent....