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In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T

Cudalbu, Cristina ; Craveiro, Melanie ; Mlynárik, Vladimir ; Bremer, Juliane ; Aguzzi, Adriano ; Gruetter, Rolf

In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Bardelli, Marco ; Frontzek, Karl ; Simonelli, Luca ; Hornemann, Simone ; Pedotti, Mattia ; Mazzola, Federica ; Carta, Manfredi ; Eckhardt, Valeria ; D’Antuono, Rocco ; Virgilio, Tommaso ; González, Santiago F. ; Aguzzi, Adriano ; Varani, Luca

In: Plos pathogens, 2018, vol. 14, no. 10, p. e1007335

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective...

The protein disulfide isomerase ERp57 regulates the steady-state levels of the prion protein

Torres, Mauricio ; Medinas,Danilo B. ; Matamala, José Manuel ; Woehlbier, Ute ; Cornejo, Víctor Hugo ; Solda, Tatiana ; Andreu, Catherine ; Rozas, Pablo ; Matus, Soledad ; Muñoz, Natalia ; Vergara, Carmen ; Cartier, Luis ; Soto, Claudio ; Molinari, Maurizio ; Hetz, Claudio

In: The journal of biological chemistry, 2015, vol. 290, no. 39, p. 23631-23645

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in Prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfide-bonded protein synthesized at the endoplasmic reticulum (ER). The ER foldase ERp57 (also known as Grp58) is highly expressed in the brain...

Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

Garschall, Kathrin ; Dellago, Hanna ; Gáliková, Martina ; Schosserer, Markus ; Flatt, Thomas ; Grillari, Johannes

In: npj Aging and Mechanisms of Disease, 2017, vol. 3, no. 1, p. 5

Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the...

Results and long-term patient satisfaction after gluteal augmentation with platelet-rich plasma-enriched autologous fat

Willemsen, Joep ; Lindenblatt, Nicole ; Stevens, Hieronymus

In: European Journal of Plastic Surgery, 2013, vol. 36, no. 12, p. 777-782

Single Transition-to-single Transition Polarization Transfer (ST2-PT) in [15N,1H]-TROSY

Pervushin, Konstantin ; Wider, Gerhard ; Wüthrich, Kurt

In: Journal of Biomolecular NMR, 1998, vol. 12, no. 2, p. 345-348

13C, 15N Resonance Assignment of Parts of the HET-s Prion Protein in its Amyloid Form

Siemer, Ansgar ; Ritter, Christiane ; Steinmetz, Michel ; Ernst, Matthias ; Riek, Roland ; Meier, Beat

In: Journal of Biomolecular NMR, 2006, vol. 34, no. 2, p. 75-87

Celebrating its 20th anniversary in 2011, the Journal of Biomolecular NMR looks forward to the second decade of the 21st century

Wüthrich, Kurt

In: Journal of Biomolecular NMR, 2011, vol. 49, no. 1, p. 1-2

Automated amino acid side-chain NMR assignment of proteins using 13C- and 15N-resolved 3D [1H,1H]-NOESY

Fiorito, Francesco ; Herrmann, Torsten ; Damberger, Fred ; Wüthrich, Kurt

In: Journal of Biomolecular NMR, 2008, vol. 42, no. 1, p. 23-33

Struktur, Assemblierung und Stabilität von Typ-1-Pili

Giese, Christoph ; Glockshuber, Rudi

In: BIOspektrum, 2013, vol. 19, no. 5, p. 492-495