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In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T

Cudalbu, Cristina ; Craveiro, Melanie ; Mlynárik, Vladimir ; Bremer, Juliane ; Aguzzi, Adriano ; Gruetter, Rolf

In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646

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    Titre
    • In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T
    Auteur
    • Cudalbu, Cristina. Centre d'Imagerie Biomedicale, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    • Craveiro, Melanie. Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    • Mlynárik, Vladimir. Centre d'Imagerie Biomedicale, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    • Bremer, Juliane. Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    • Aguzzi, Adriano. Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    • Gruetter, Rolf. Centre d'Imagerie Biomedicale, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:333073
    Summary
    In vivo 1H MR spectroscopy allows the non invasive characterization of brain metabolites and it has been used for studying brain metabolic changes in a wide range of neurodegenerative diseases. The prion diseases form a group of fatal neurodegenerative diseases, also described as transmissible spongiform encephalopathies. The mechanism by which prions elicit brain damage remains unclear and therefore different transgenic mouse models of prion disease were created. We performed an in vivo longitudinal 1H MR spectroscopy study at 14.1T with the aim to measure the neurochemical profile of Prnp -/- and PrPΔ32-121 mice in the hippocampus and cerebellum. Using high-field MR spectroscopy we were able to analyze in details the in vivo brain metabolites in Prnp -/- and PrPΔ32-121 mice. An increase of myo-inositol, glutamate and lactate concentrations with a decrease of N-acetylaspartate concentrations were observed providing additional information to the previous measurements.