Perfeziona i miei risultati

Document type

Collection spécifique

Lingua

Università della Svizzera italiana

Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA

Lepre, Marco Gaetano ; Omar, Sara Ibrahim ; Grasso, Gianvito ; Morbiducci, Umberto ; Deriu, Marco Agostino ; Tuszynski, Jack A.

In: Molecules, 2017, vol. 22, no. 8, p. 1358

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...

Università della Svizzera italiana

Conformational dynamics and stability of U-shaped and S-shaped amyloid β assemblies

Grasso, Gianvito ; Rebella, Martina ; Muscat, Stefano ; Morbiducci, Umberto ; Tuszynski, Jack ; Danani, Andrea ; Deriu, Marco A.

In: International journal of molecular sciences, 2018, vol. 19, no. 2, p. 571

Alzheimer’s disease is the most fatal neurodegenerative disorder characterized by the aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two principal variants of Aβ exist in humans: Aβ1–40 and Aβ1–42. The former is the most abundant in the plaques, while the latter is the most toxic species and forms fibrils more rapidly. Interestingly, fibrils of...

Université de Fribourg

Nonequilibrium solid-solid phase transition in a lattice of liquid jets

Croccolo, Fabrizio ; Castellini, Stefano ; Scheffold, Frank ; Vailati, Alberto

In: Physical Review E, 2018, vol. 98, no. 6, p. 063104

Solid-solid phase transitions are commonly encountered at the atomic scale in alloys and in superatomic mesoscopic systems of colloidal particles. Here we investigate a solid-solid phase transition occurring at the macroscopic scale between lattices of liquid jets with different symmetries generated by convection in a horizontal layer of a binary liquid mixture. In the absence of a shear...

Consortium of Swiss Academic Libraries

The emerging energy web

Ajmone-Marsan, M. ; Arrowsmith, D. ; Breymann, W. ; Fritz, O. ; Masera, M. ; Mengolini, A. ; Carbone, A.

In: The European Physical Journal Special Topics, 2012, vol. 214, no. 1, p. 547-569

Consortium of Swiss Academic Libraries

Gravitational lensing and rotation curve

Bräunlich, Gerhard ; Scharf, Günter

In: General Relativity and Gravitation, 2011, vol. 43, no. 1, p. 143-154