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Université de Fribourg

CD47 promotes age-associated deterioration in angiogenesis, blood flow and glucose homeostasis

Ghimire, Kedar ; Li, Yao ; Chiba, Takuto ; Julovi, Sohel M. ; Li, Jennifer ; Ross, Mark A. ; Straub, Adam C. ; O’Connell, Philip J. ; Rüegg, Curzio ; Pagano, Patrick J. ; Isenberg, Jeffrey S. ; Rogers, Natasha M.

In: Cells, 2020, vol. 9, no. 7, p. 1695

The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...

Université de Fribourg

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Abdollahi Govar, Armita ; Törő, Gábor ; Szaniszlo, Peter ; Pavlidou, Athanasia ; Bibli, Sofia‐Iris ; Thanki, Ketan ; Resto, Vicente A. ; Chao, Celia ; Hellmich, Mark R. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Módis, Katalin

In: British Journal of Pharmacology, 2020, vol. 177, no. 4, p. 866–883

During angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre‐existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date, very little is known about the regulatory role of...

Université de Fribourg

Absorb bioresorbable scaffold versus xience metallic stent for prevention of restenosis following percutaneous coronary intervention in patients at high risk of restenosis: rationale and design of the COMPARE ABSORB trial

Chang, Chun Chin ; Onuma, Yoshinobu ; Achenbach, Stephan ; Barbato, Emanuele ; Chevalier, Bernard ; Cook, Stéphane ; Dudek, Dariusz ; Escaned, Javier ; Gori, Tommaso ; Kočka, Viktor ; Tarantini, Giuseppe ; E.J.West, Nick ; Morice, Marie-Claude ; G.P.Tijssen, Jan ; Geuns, Robert-Janvan ; C.Smits, Pieter

In: Cardiovascular Revascularization Medicine, 2019, vol. 20, no. 7, p. 577–582

Background: The advent of bioresorbable vascular scaffolds (BVS) was considered as a potential improvement in percutaneous coronary intervention (PCI) after the groundbreaking development of drug eluting stents (DES). However, the clinical performance, long-term safety and efficacy of BVS in complex coronary lesions remain uncertain. COMPARE ABSORB, a multicenter, single blind, prospective ...