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Acquisition of extended-spectrum β-lactamase GES-6 leading to resistance to ceftolozane-tazobactam combination in Pseudomonas aeruginosa

Poirel, Laurent ; Ortiz De La Rosa, José-Manuel ; Kieffer, Nicolas ; Dubois, Véronique ; Jayol, Aurélie ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 1, p. e01809-18

A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a ...

Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens

Dobias, Jan ; Dénervaud-Tendon, Valérie ; Poirel, Laurent ; Nordmann, Patrice

In: European Journal of Clinical Microbiology & Infectious Diseases, 2017, p. 1–9

The novel siderophore cephalosporin cefiderocol (S-649266) with potent activity against Gram-negative pathogens was recently developed (Shionogi & Co., Ltd.). Here, we evaluated the activity of this new molecule and comparators against a collection of previously characterized Gram-negative isolates using broth microdilution panels. A total of 753 clinical multidrug-resistant Gram-negative...

Acute Cytomegalovirus Colitis Presenting during Primary HIV Infection: an Unusual Case of an Immune Reconstitution Inflammatory Syndrom

von Both, Ulrich ; Laffer, Reto ; Grube, Christina ; Bossart, Walter ; Gaspert, Ariana ; Gü nthard, Huldrych F.

In: Clinical Infectious Diseases, 2008, vol. 46, no. 4, p. e38-e40

African Immigrant with Weight Loss and Disseminated Skin Lesions

Mackowiak, Philip A. ; Mackowiak, Philip A. ; Hasse, Barbara ; Kronenberg, Andreas

In: Clinical Infectious Diseases, 2003, vol. 37, no. 5, p. 726-727

Actinomyces neuii Isolated From a 20-Month-Old Girl With Cervical Lymphadenitis

Walther, Kathi ; Bruder, Elisabeth ; Goldenberger, Daniel ; Mayr, Johannes ; Schaad, Urs Beat ; Ritz, Nicole

In: Journal of the Pediatric Infectious Diseases Society, 2015, vol. 4, no. 3, p. e32-e37

Adult native septic arthritis: a review of 10 years of experience and lessons for empirical antibiotic therapy

Clerc, Olivier ; Prod'hom, Guy ; Greub, Gilbert ; Zanetti, Giorgio ; Senn, Laurence

In: Journal of Antimicrobial Chemotherapy, 2011, vol. 66, no. 5, p. 1168-1173

2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adultsa

Berbari, Elie F. ; Kanj, Souha S. ; Kowalski, Todd J. ; Darouiche, Rabih O. ; Widmer, Andreas F. ; Schmitt, Steven K. ; Hendershot, Edward F. ; Holtom, Paul D. ; Huddleston, Paul M. ; Petermann, Gregory W. ; Osmon, Douglas R.

In: Clinical Infectious Diseases, 2015, vol. 61, no. 6, p. e26-e46

Additive Effect of Enterococcus faecium on Enterococcal Bloodstream Infections: A 14-Year Study in a Swiss Tertiary Hospital

Weisser, Maja ; Capaul, Selja ; Dangel, Marc ; Elzi, Luigia ; Kuenzli, Esther ; Frei, Reno ; Widmer, Andreas

In: Infection Control & Hospital Epidemiology, 2013, vol. 34, no. 10, p. 1109-1112

Acquisition of broad-spectrum cephalosporin resistance leading to colistin resistance in Klebsiella pneumoniae

Jayol, Aurélie ; Nordmann, Patrice ; Desroches, Marine ; Decousser, Jean-Winoc ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 5, p. 3199–3201

An extended-spectrum β-lactamase (ESBL)-producing and colistin-resistant Klebsiella pneumoniae clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored a blaCTX-M-15 ESBL gene that was associated with an ISEcp1 insertion sequence. Transposition of that tandem occurred within the chromosomal mgrB gene, leading...

About the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing Escherichia coli

Zahar, Jean-Ralph ; Poirel, Laurent ; Dupont, Claire ; Fortineau, Nicolas ; Nassif, Xavier ; Nordmann, Patrice

In: BMC Infectious Diseases, 2015, vol. 15, p. 512

Extended-spectrum β-lactamases producing Escherichia coli (ESBL-E) are increasingly identified in health care facilities. As previously done for the control of methicillin-resistant Staphylococcus aureus, many hospitals have established screening strategies for early identification of patients being carriers of ESBL producers in general and ESBL-E in particular, and have implemented contact...