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Université de Fribourg

Efficacy of colistin alone and in various combinations for the treatment of experimental osteomyelitis due to carbapenemase-producing Klebsiella pneumoniae

Crémieux, Anne-Claude ; Dinh, Aurélien ; Nordmann, Patrice ; Mouton, William ; Tattevin, Pierre ; Ghout, Idir ; Jayol, Aurelie ; Aimer, Omar ; Gatin, Laure ; Verdier, Marie-Clémence ; Saleh-Mghir, Azzam ; Laurent, Frédéric

In: Journal of Antimicrobial Chemotherapy, 2019, vol. 74, no. 9, p. 2666–2675

Objectives: In a new experimental model of carbapenemase-producing Klebsiella pneumoniae osteomyelitis we evaluated the efficacy of colistin alone and in various combinations and examined the emergence of colistin-resistant strains and cross- resistance to host defence peptides (HDPs).Methods: KPC-99YC is a clinical strain with intermediate susceptibility to meropenem (MIC = 4 mg/L) and...

Università della Svizzera italiana

HTLV-1 propels thymic human T cell development in “human immune system” Rag2-/- gamma c-/- Mice

Villaudy, Julien ; Wencker, Mélanie ; Gadot, Nicolas ; Gillet, Nicolas A. ; Scoazec, Jean-Yves ; Gazzolo, Louis ; Manz, Markus G. ; Bangham, Charles R. M. ; Duc Dodon, Madeleine

In: Plos pathogens, 2011, vol. 7, no. 9, p. e1002231

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that TaxHTLV-1 interferes with ß- selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human αβ T-cell development. To...

Consortium of Swiss Academic Libraries

Ocular manifestations in congenital toxoplasmosis

Kodjikian, Laurent ; Wallon, Martine ; Fleury, Jacques ; Denis, Philippe ; Binquet, Christine ; Peyron, François ; Garweg, Justus

In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2006, vol. 244, no. 1, p. 14-21