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Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart

Jamilloux, Yvan ; Gerfaud-Valentin, Mathieu ; Martinon, Fabio ; Belot, Alexandre ; Henry, Thomas ; Sève, Pascal

In: Immunologic Research, 2015, vol. 61, no. 1-2, p. 53-62

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    Titre
    • Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart
    Auteur
    • Jamilloux, Yvan. Department of Internal Medicine, Hopital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004, Lyon, France
    • Gerfaud-Valentin, Mathieu. Department of Internal Medicine, Hopital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004, Lyon, France
    • Martinon, Fabio. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    • Belot, Alexandre. University Claude Bernard-Lyon 1, Lyon, France
    • Henry, Thomas. University Claude Bernard-Lyon 1, Lyon, France
    • Sève, Pascal. Department of Internal Medicine, Hopital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004, Lyon, France
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Immunologic Research, 2015, vol. 61, no. 1-2, p. 53-62. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332069
    Summary
    Adult-onset Still's disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.