Affiner les résultats

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Scherrer, Alexandra U.

In: Journal of Infectious Diseases, ///-

Antiviral drug resistance as an adaptive process

Irwin, Kristen K. ; Renzette, Nicholas ; Kowalik, Timothy F. ; Jensen, Jeffrey D.

In: Virus Evolution, 2016, vol. 2, no. 1, p. -

Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice

Hauber, Ilona ; Hofmann-Sieber, Helga ; Chemnitz, Jan ; Dubrau, Danilo ; Chusainow, Janet ; Stucka, Rolf ; Hartjen, Philip ; Schambach, Axel ; Ziegler, Patrick ; Hackmann, Karl ; Schröck, Evelin ; Schumacher, Udo ; Lindner, Christoph ; Grundhoff, Adam ; Baum, Christopher ; Manz, Markus G. ; Buchholz, Frank ; Hauber, Joachim

In: Plos pathogens, 2013, vol. 9, no. 9, p. e1003587

Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro,...

The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity

Valaperti, Alan ; Nishii, Mototsugu ; Liu, Youan ; Yang, Howard ; Naito, Kotaro ; Liu, Peter ; Eriksson, Urs

In: Basic Research in Cardiology, 2014, vol. 109, no. 3, p. 1-14

Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity

Rus, Florentina ; Flatt, Thomas ; Tong, Mei ; Aggarwal, Kamna ; Okuda, Kendi ; Kleino, Anni ; Yates, Elisabeth ; Tatar, Marc ; Silverman, Neal

In: The EMBO Journal, 2013, vol. 32, no. 11, p. 1626–1638

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial...

Interferon alpha-2a Plus Ribavirin 1,000/1,200 mg versus Interferon alpha-2a Plus Ribavirin 600 mg for Chronic Hepatitis C Infection in Patients on Opiate Maintenance Treatment: An Open-Label Randomized Multicenter Trial

Huber, M. ; Weber, R. ; Oppliger, R. ; Vernazza, P. ; Schmid, P. ; Schönbucher, P. ; Bertisch, B. ; Meili, D. ; Renner, E.

In: Infection, 2005, vol. 33, no. 1, p. 25-29

Therapeutic drug monitoring by LC-MS-MS with special focus on anti-infective drugs

Müller, Daniel ; Rentsch, Katharina

In: Analytical and Bioanalytical Chemistry, 2010, vol. 398, no. 6, p. 2573-2594

Reactive oxygen species and nitric oxide in viral diseases

Peterhans, Ernst

In: Biological Trace Element Research, 1997, vol. 56, no. 1, p. 107-116

Emerging roles of pathogens in Alzheimer disease

Miklossy, Judith

In: Expert Reviews in Molecular Medicine, 2011, vol. 13, p. -

Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process

Salata, Cristiano ; Baritussio, Aldo ; Munegato, Denis ; Calistri, Arianna ; Ha, Huy Riem ; Bigler, Laurent ; Fabris, Fabrizio ; Parolin, Cristina ; Palù, Giorgio ; Mirazimi, Ali ; Garzino-Demo, Alfredo

In: Pathogens and Disease, 2015, vol. 73, no. 5, p. -