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Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Scherrer, Alexandra U.

In: Journal of Infectious Diseases, ///-

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    Titre
    • Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study
    Auteur
    • Scherrer, Alexandra U.
    Contributeur
    • Yang, Wan-Lin. joint author
    • Kouyos, Roger D.. joint author
    • Böni, Jürg. joint author
    • Yerly, Sabine. joint author
    • Klimkait, Thomas. joint author
    • Aubert, Vincent. joint author
    • Cavassini, Matthias. joint author
    • Battegay, Manuel. joint author
    • Hauser, Christoph. joint author
    • Calmy, Alexandra. joint author
    • Schmid, Patrick. joint author
    • Bernasconi, Enos. joint author
    • Günthard, Huldrych F.. joint author
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332796
    Summary
    The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.