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The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity

Hess, Christian ; Neri, Dario

In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 5, p. 635-644

Unsupervised template discovery in activity recognition using the Gamma Growing Neural Gas algorithm

Satizábal, Héctor ; Perez-Uribe, Andres

In: Soft Computing, 2015, vol. 19, no. 9, p. 2435-2445

Reply to Planet et al

François, Patrice ; von Dach, Elodie ; Diene, Seydina M. ; Harbarth, Stephan ; Schrenzel, Jacques

In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1610-1611

The immunomodulatory effects of macrolides - a systematic review of the underlying mechanisms

Zimmermann, Petra ; Ziesenitz, Victoria C. ; Curtis, Nigel ; Ritz, Nicole

In: Frontiers in Immunology, 2018, vol. 9, p. -

The mechanisms underlying the non-antimicrobial immunomodulatory properties of macrolides are not well understood.Objectives: To systematically review the evidence for the immunomodulatory properties of macrolides in humans and to describe the underlying mechanism and extent of their influence on the innate and adaptive immune system.Methods: A systematic literature search was done in MEDLINE...

Molecular signatures of immunity and immunogenicity in infection and vaccination

Haks, Mariëlle C. ; Bottazzi, Barbara ; Cecchinato, Valentina ; De Gregorio, Corinne ; Del Giudice, Giuseppe ; Kaufmann, Stefan H. E. ; Lanzavecchia, Antonio ; Lewis, David J. M. ; Maertzdorf, Jeroen ; Mantovani, Alberto ; Sallusto, Federica ; Sironi, Marina ; Uguccioni, Mariagrazia ; Ottenhoff, Tom H. M.

In: Frontiers in immunology, 2017, vol. 8, p. 1563

Vaccinology aims to understand what factors drive vaccine-induced immunity and protection. For many vaccines, however, the mechanisms underlying immunity and protection remain incompletely characterized at best, and except for neutralizing antibodies induced by viral vaccines, few correlates of protection exist. Recent omics and systems biology big data platforms have yielded valuable...

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors

Quakkelaar, Esther D. ; Redeker, Anke ; Haddad, Elias K. ; Harari, Alexandre ; McCaughey, Stella Mayo ; Duhen, Thomas ; Filali-Mouhim, Abdelali ; Goulet, Jean-Philippe ; Loof, Nikki M. ; Ossendorp, Ferry ; Perdiguero, Beatriz ; Heinen, Paul ; Gomez, Carmen E. ; Kibler, Karen V. ; Koelle, David M. ; Sékaly, Rafick P. ; Sallusto, Federica ; Lanzavecchia, Antonio ; Pantaleo, Giuseppe ; Esteban, Mariano ; Tartaglia, Jim ; Jacobs, Bertram L. ; Melief, Cornelis J. M.

In: Plos one, 2011, vol. 6, no. 2, p. e16819

Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune response. This manuscript describes two strategies aimed to improve the immunogenicity of the...

Epidemiology of childhood tuberculosis in Switzerland between 1996 and 2011

Oesch Nemeth, Gabriela ; Nemeth, Johannes ; Altpeter, Ekkehardt ; Ritz, Nicole

In: European Journal of Pediatrics, 2014, vol. 173, no. 4, p. 457-462

IGRA-positive patients and interferon-gamma/interleukin-2 signatures: Can the Fluorospot assay provide further information?

Bittel, P. ; Mayor, D. ; Iseli, P. ; Bodmer, T. ; Suter-Riniker, F.

In: Infection, 2014, vol. 42, no. 3, p. 539-543

The sensitivity of an interferon-γ release assay in microbiologically confirmed pediatric tuberculosis

Schopfer, Kurt ; Rieder, Hans ; Bodmer, Thomas ; Steinlin-Schopfer, Jacqueline ; Chantana, Yay ; Studer, Peter ; Laurent, Denis ; Richner, Beat

In: European Journal of Pediatrics, 2014, vol. 173, no. 3, p. 331-336

Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage in women from former Yugoslavia living in Switzerland

Marschall, J. ; Dürig, P. ; Mühlemann, K.

In: European Journal of Clinical Microbiology and Infectious Diseases, 2006, vol. 25, no. 8, p. 535-536