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E-selectin ligand complexes adopt an extended high-affinity conformation

Preston, Roland C. ; Jakob, Roman P. ; Binder, Florian P.C. ; Sager, Christoph P. ; Ernst, Beat ; Maier, Timm

In: Journal of Molecular Cell Biology, 2016, vol. 8, no. 1, p. 62-72

Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer

Paul, Lydia ; Therrien, Bruno ; Furrer, Julien

In: JBIC Journal of Biological Inorganic Chemistry, 2015, vol. 20, no. 1, p. 49-59

Effects of Tailored Surface Chemistry on Desorption Electrospray Ionization Mass Spectrometry: a Surface-Analytical Study by XPS and AFM

Penna, Andrea ; Careri, Maria ; Spencer, Nicholas ; Rossi, Antonella

In: Journal of The American Society for Mass Spectrometry, 2015, vol. 26, no. 8, p. 1311-1319

Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors

Maruca, Annalisa ; Lanzillotta, Delia ; Rocca, Roberta ; Lupia, Antonio ; Costa, Giosuè ; Catalano, Raffaella ; Moraca, Federica ; Gaudio, Eugenio ; Ortuso, Francesco ; Artese, Anna ; Trapasso, Francesco ; Alcaro, Stefano

In: Molecules, 2020, vol. 25, no. 9, p. 14 p

Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti- cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand,...

In vitro cytotoxicity and catalytic evaluation of dioxidovanadium(V) complexes in an azohydrazone ligand environment

Mohanty, Monalisa ; Maurya, Shailendra K. ; Banerjee, Atanu ; Patra, Sushree Aradhana ; Maurya, Mannar R. ; Crochet, Aurélien ; Brzezinski, Krzysztof ; Dinda, Rupam

In: New Journal of Chemistry, 2019, vol. 43, no. 45, p. 17680–17695

Three new anionic dioxidovanadium(V) complexes (HNEt3)[VO2(L)1–3] (1–3) of tridentate binegative aroylhydrazone ligands containing the azobenzene moiety were synthesized and structurally characterized. The aroylhydrazone ligands (H2L1–3) were derived from the condensation of 5-(arylazo) salicylaldehyde derivatives with the corresponding aroyl hydrazides. All the synthesized ligands and...

Rational modification of estrogen receptor by combination of computational and experimental analysis

Ferrero, Valentina Elisabetta Viviana ; Pedotti, Mattia ; Chiadò, Alessandro ; Simonelli, Luca ; Calzolai, Luigi ; Varani, Luca ; Lettieri, Teresa

In: Plos one, 2014, vol. 9, no. 7, p. e102658

In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor- ligand complexes with computational analysis, we were able to predict estrogen receptor mutants with altered binding properties. These predictions...

Erratum to: Quantifying Protein-Ligand Binding Constants Using Electrospray Ionization Mass Spectrometry: A Systematic Binding Affinity Study of a Series of Hydrophobically Modified Trypsin Inhibitors

Cubrilovic, Dragana ; Biela, Adam ; Sielaff, Frank ; Steinmetzer, Torsten ; Klebe, Gerhard ; Zenobi, Renato

In: Journal of The American Society for Mass Spectrometry, 2014, vol. 25, no. 7, p. 1305-1305

Dynamic aggregation of the mid-sized gadolinium complex {Ph4[Gd(DTTA)(H2O)2]− 3}

Jaccard, Hugues ; Miéville, Pascal ; Cannizzo, Caroline ; Mayer, Cédric ; Helm, Lothar

In: JBIC Journal of Biological Inorganic Chemistry, 2014, vol. 19, no. 2, p. 145-159

A ToF-MS with a Highly Efficient Electrostatic Ion Guide for Characterization of Ionic Liquid Electrospray Sources

Chakraborty, Subha ; Ataman, Caglar ; Courtney, Daniel ; Dandavino, Simon ; Shea, Herbert

In: Journal of The American Society for Mass Spectrometry, 2014, vol. 25, no. 8, p. 1364-1373

Phenotyping of CYP450 in human liver microsomes using the cocktail approach

Spaggiari, Dany ; Geiser, Laurent ; Daali, Youssef ; Rudaz, Serge

In: Analytical and Bioanalytical Chemistry, 2014, vol. 406, no. 20, p. 4875-4887