In: Journal of Investigative Dermatology, 2020, vol. 140, no. 11, p. 2280-2290.e4
Chronic skin wounds accompany many prevalent age-related diseases and are a major cause of morbidity and mortality. Both keratinocytes and fibroblasts contribute to the pathomechanisms in chronic skin wounds. Dysregulated pathways in the epidermis have been extensively studied, but little is known of the influence of dermal fibroblasts on chronic wounding. We isolated fibroblasts from chronic...
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In: Particle and Fibre Toxicology, 2020, vol. 17, no. 1, p. 35
Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution- associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles.Main text: To date, most of the research studies did focus on the...
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In: Scientific reports, 2017, vol. 7, p. 11657
The effects of epicutaneous allergen administration on systemic immune responses in allergic and non-allergic individuals has not been investigated with defined allergen molecules. We studied the effects of epicutaneous administration of rBet v 1 and rBet v 1 fragments on systemic immune responses in allergic and non-allergic subjects. We conducted a clinical trial in which rBet v 1 and two...
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In: Nature communications, 2016, vol. 7, p. 13466
Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. Aside from neutralizing IL-23, which is thought to be responsible for the curative effect, anti-p40 therapy also interferes with IL-12 signalling and type 1 immunity. Here we dissect the individual contribution of these two cytokines to the...
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In: Archives of Dermatological Research, 2014, vol. 306, no. 10, p. 933-938
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In: Advances in Therapy, 2014, vol. 31, no. 2, p. 180-188
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In: Seminars in Immunopathology, 2014, vol. 36, no. 5, p. 519-529
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In: Proceedings of the national academy of sciences, 2017, vol. 114, no. 8, p. E1490-E1499
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using...
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In: Archives of Dermatological Research, 2005, vol. 296, no. 10, p. 503-506
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In: World Journal of Pediatrics, 2012, vol. 8, no. 2, p. 173-176
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