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Effects of potato-derived protease inhibitors on perianal dermatitis after colon resection for long-segment Hirschsprung's disease

Berger, Steffen ; Rufener, Janine ; Klimek, Peter ; Zachariou, Zacharias ; Boillat, Colette

In: World Journal of Pediatrics, 2012, vol. 8, no. 2, p. 173-176

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    Titre
    • Effects of potato-derived protease inhibitors on perianal dermatitis after colon resection for long-segment Hirschsprung's disease
    Auteur
    • Berger, Steffen. Department of Pediatric Surgery, Children's University Hospital, Inselspital, University of Bern, CH-3010, Bern, Switzerland
    • Rufener, Janine. Department of Pediatric Surgery, Children's University Hospital, Inselspital, University of Bern, CH-3010, Bern, Switzerland
    • Klimek, Peter. Department of Pediatric Surgery, Children's University Hospital, Inselspital, University of Bern, CH-3010, Bern, Switzerland
    • Zachariou, Zacharias. Department of Pediatric Surgery, Children's University Hospital, Inselspital, University of Bern, CH-3010, Bern, Switzerland
    • Boillat, Colette. Department of Pediatric Surgery, Children's University Hospital, Inselspital, University of Bern, CH-3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • World Journal of Pediatrics, 2012, vol. 8, no. 2, p. 173-176. SP Children's Hospital, Zhejiang University School of Medicine
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315830
    Summary
    Background: After resection of long-segment Hirschsprung's disease, severe perianal dermatitis (SPAD) may occur because of high stool frequency and elevated concentrations of fecal pancreatic proteases. We investigated prospectively the effect of potato-derived protease inhibitors (PPI) on skin conditions in children with postoperative SPAD. Methods: Four children (aged 12 to 24 months) with therapy-resistant SPAD after transanal endorectal pull-through for long-segment Hirschsprung's disease received topical PPI (1% in 20% zinc ointment) with each diaper-change. Parents noted down a subjective dermatitis score daily. Photo documentation and outpatient visits were made to assess the treatment results. Results: No adverse effects were observed after treatment with PPI. A remarkable improvement of the dermatitis in 3 of the 4 patients as well as improvements in pain and sleep disorders were observed during the PPI-treatment course. Conclusion: The results of the study suggest that PPI may reduce otherwise intractable protease-induced skin irritation in infants