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Role of connexins and pannexins in cardiovascular physiology

Meens, Merlijn ; Kwak, Brenda ; Duffy, Heather

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2779-2792

The lung communication network

Losa, Davide ; Chanson, Marc

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2793-2808

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Ex vivo analysis of kidney graft viability using 31p magnetic resonance imaging spectroscopy

Longchamp, Alban ; Klauser, Antoine ; Songeon, Julien ; Agius, Thomas ; Nastasi, Antonio ; Ruttiman, Raphael ; Moll, Solange ; Meier, Raphael P. H. ; Buhler, Leo ; Corpataux, Jean-Marc ; Lazeyras, Francois

In: Transplantation, 2020, vol. 104, no. 9, p. 1825–1831

Background: The lack of organs for kidney transplantation is a growing concern. Expansion in organ supply has been proposed through the use of organs after circulatory death (donation after circulatory death [DCD]). However, many DCD grafts are discarded because of long warm ischemia times, and the absence of reliable measure of kidney viability. 31P magnetic resonance imaging (pMRI)...

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...

Dependence of immunoglobulin class switch recombination in B Cells on vesicular release of ATP and CD73 ectonucleotidase activity

Schena, Francesca ; Volpi, Stefano ; Faliti, Caterina Elisa ; Penco, Federica ; Santi, Spartaco ; Proietti, Michele ; Schenk, Ursula ; Damonte, Gianluca ; Salis, Annalisa ; Bellotti, Marta ; Fais, Franco ; Tenca, Claudya ; Gattorno, Marco ; Eibel, Hermann ; Rizzi, Marta ; Warnatz, Klaus ; Idzko, Marco ; Ayata, Cemil Korcan ; Rakhmanov, Mirzokhid ; Galli, Thierry ; Martini, Alberto ; Canossa, Marco ; Grassi, Fabio ; Traggiai, Elisabetta

In: Cell report, 2013, vol. 3, no. 6, p. 1824-1831

Immunoglobulin (Ig) isotype diversification by class switch recombination (CSR) is an essential process for mounting a protective humoral immune response. Ig CSR deficiencies in humans can result from an intrinsic B cell defect; however, most of these deficiencies are still molecularly undefined and diagnosed as common variable immunodeficiency (CVID). Here, we show that extracellular...

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Winnik, Stephan ; Gaul, Daniel ; Preitner, Frédéric ; Lohmann, Christine ; Weber, Julien ; Miranda, Melroy ; Liu, Yilei ; van Tits, Lambertus ; Mateos, José ; Brokopp, Chad ; Auwerx, Johan ; Thorens, Bernard ; Lüscher, Thomas ; Matter, Christian

In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15

Monitoring of Brain and Systemic Oxygenation in Neurocritical Care Patients

Oddo, Mauro ; Bösel, Julian

In: Neurocritical Care, 2014, vol. 21, p. 103-120

P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells

Gailly, P. ; Szutkowska, M. ; Olinger, E. ; Debaix, H. ; Seghers, F. ; Janas, S. ; Vallon, V. ; Devuyst, O.

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 11, p. 2035-2047

Comparison of the π-stacking properties of purine versus pyrimidine residues. Some generalizations regarding selectivity

Sigel, Astrid ; Operschall, Bert ; Sigel, Helmut

In: JBIC Journal of Biological Inorganic Chemistry, 2014, vol. 19, no. 4-5, p. 691-703