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The lung communication network

Losa, Davide ; Chanson, Marc

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2793-2808

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    Titre
    • The lung communication network
    Auteur
    • Losa, Davide. Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland
    • Chanson, Marc. Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2793-2808. Springer Basel
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331046
    Summary
    The different types of cells in the lung, from the conducting airway epithelium to the alveolar epithelium and the pulmonary vasculature, are interconnected by gap junctions. The specific profile of gap junction proteins, the connexins, expressed in these different cell types forms compartments of intercellular communication that can be further shaped by the release of extracellular nucleotides via pannexin1 channels. In this review, we focus on the physiology of connexins and pannexins and describe how this lung communication network modulates lung function and host defenses in conductive and respiratory airways.