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Université de Fribourg

The karrikin signaling regulator SMAX1 controls Lotus japonicus root and root hair development by suppressing ethylene biosynthesis

Carbonnel, Samy ; Dasa, Debatosh ; Varshney, Kartikye ; Kolodziej, Markus C. ; Villaécija-Aguilar, José A. ; Gutjahr, Caroline

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 35, p. 21757–21765

An evolutionarily ancient plant hormone receptor complex comprising the α/β-fold hydrolase receptor KARRIKIN INSENSITIVE 2 (KAI2) and the F-box protein MORE AXILLARY GROWTH 2 (MAX2) mediates a range of developmental responses to smoke-derived butenolides called karrikins (KARs) and to yet elusive endogenous KAI2 ligands (KLs). Degradation of SUPPRESSOR OF MAX2 1 (SMAX1) after ligand ...

Università della Svizzera italiana

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo

Rota, Giorgia ; Niogret, Charlène ; Dang, Anh Thu ; Ramon Barros, Cristina ; Fonta, Nicolas Pierre ; Alfei, Francesca ; Morgado, Leonor ; Zehn, Dietmar ; Birchmeier, Walter ; Vivier, Eric ; Guarda, Greta

In: Cell reports, 2018, vol. 23, no. 1, p. 39-49

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...

Université de Fribourg

When black and white make green: the surprising interplay of structure and pigments

Sai, Tianqi ; Wilts, Bodo D. ; Sicher, Alba ; Steiner, Ullrich ; Scheffold, Frank ; Dufresne, Eric R.

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 47–50

The natural world is teeming with color, which originates either from the wavelength- dependent absorp- tion of light by pigments or from scattering from nanoscale structures, or both. While the latter ' structural color ' has been a topic of intense study in recent years, the most vibrant colors in nature involve contributions from both structure and pigment. The study of structure–pigment...