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Université de Fribourg

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...

Université de Fribourg

Phenotypic, biochemical, and genetic analysis of kpc-41, a kpc-3 variant conferring resistance to ceftazidime-avibactam and exhibiting reduced carbapenemase activity

Mueller, Linda ; Masseron, Amandine ; Prod’Hom, Guy ; Galperine, Tatiana ; Greub, Gilbert ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 12, p. -

A novel KPC variant, KPC-41, was identified in a Klebsiella pneumoniae clinical isolate from Switzerland. This β-lactamase possessed a 3-amino-acid insertion (Pro- Asn-Lys) located between amino acids 269 and 270 compared to the KPC-3 amino acid sequence. Cloning and expression of the blaKPC-41 gene in Escherichia coli, followed by determination of MIC values and kinetic parameters, showed...

Consortium of Swiss Academic Libraries

Antibiotics and Staphylococcus aureus —more than meets the MIC

Howden, Benjamin

In: Journal of Molecular Medicine, 2014, vol. 92, no. 2, p. 103-106

Consortium of Swiss Academic Libraries

Variability of SCC mec in the Zurich area

Ender, M. ; Burger, S. ; Sokoli, A. ; Zbinden, R. ; Berger-Bächi, B. ; Heusser, R. ; Senn, M. ; McCallum, N.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2009, vol. 28, no. 6, p. 647-653