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Université de Fribourg

Swiss consensus recommendations on urinary tract infections in children

Buettcher, Michael ; Trueck, Johannes ; Niederer-Loher, Anita ; Heininger, Ulrich ; Agyeman, Philipp ; Asner, Sandra ; Berger, Christoph ; Bielicki, Julia ; Kahlert, Christian ; Kottanattu, Lisa ; Meyer Sauteur, Patrick M. ; Paioni, Paolo ; Posfay-Barbe, Klara ; Relly, Christa ; Ritz, Nicole ; Zimmermann, Petra ; Zucol, Franziska ; Gobet, Rita ; Shavit, Sandra ; Rudin, Christoph ; Laube, Guido ; von Vigier, Rodo ; Neuhaus, Thomas J.

In: European Journal of Pediatrics, 2020, p. -

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. The differentiation between...

Université de Fribourg

Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Martín-Ruiz, Asunción ; Fiuza-Luces, Carmen ; Martínez-Martínez, Esther ; Arias, Clemente F. ; Gutiérrez, Lourdes ; Ramírez, Manuel ; Martín-Acosta, Paloma ; Coronado, Maria José ; Lucia, Alejandro ; Provencio, Mariano

In: Scientific Reports, 2020, vol. 10, no. 1, p. 7078

Immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), have resulted in unprecedented improvements in survival for patients with lung cancer. Nonetheless, not all patients benefit equally and many issues remain unresolved, including the mechanisms of action and the possible effector function of immune cells from non-lymphoid lineages. The purpose of this...

Université de Fribourg

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...