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In: Annals of Biomedical Engineering, 2015, vol. 43, no. 7, p. 1600-1613
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In: Clinical Research in Cardiology, 2015, vol. 104, no. 2, p. 136-144
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In: Medizinische Klinik - Intensivmedizin und Notfallmedizin, ///-
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In: Future Medicinal Chemistry, 2013, vol. 5, no. 2, p. 175-188
Since the discovery that CO acts as a cytoprotective and homeostatic molecule, increasing research efforts have been devoted to the exploitation of its therapeutic effects. Both endogenous and exogenous CO improves experimental lung, vascular and cardiac injuries and protects against several inflammatory states. The technology is now in place to bring CO to clinical applications, but the use...
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In: Biomolecules, 2020, vol. 10, no. 5, p. 697
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with...
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In: Cancers, 2019, vol. 11, no. 7, p. 978
Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...
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