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Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy

Taniwaki, Masanori ; Radu, Maria ; Garcia-Garcia, Hector ; Heg, Dik ; Kelbæk, Henning ; Holmvang, Lene ; Moschovitis, Aris ; Noble, Stephane ; Pedrazzini, Giovanni ; Saunamäki, Kari ; Dijkstra, Jouke ; Landmesser, Ulf ; Wenaweser, Peter ; Meier, Bernhard ; Stefanini, Giulio ; Roffi, Marco ; Lüscher, Thomas ; Windecker, Stephan ; Räber, Lorenz

In: The International Journal of Cardiovascular Imaging, 2015, vol. 31, no. 5, p. 915-926

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    Titre
    • Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy
    Auteur
    • Taniwaki, Masanori. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Radu, Maria. Rigshospitalet, Copenhagen, Denmark
    • Garcia-Garcia, Hector. Erasmus MC, Rotterdam, The Netherlands
    • Heg, Dik. Clinical Trial Unit, University of Bern, Bern, Switzerland
    • Kelbæk, Henning. Rigshospitalet, Copenhagen, Denmark
    • Holmvang, Lene. Rigshospitalet, Copenhagen, Denmark
    • Moschovitis, Aris. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Noble, Stephane. University Hospital, Geneva, Switzerland
    • Pedrazzini, Giovanni. Cardiocentro, Lugano, Switzerland
    • Saunamäki, Kari. Rigshospitalet, Copenhagen, Denmark
    • Dijkstra, Jouke. Leiden University Medical Center, Leiden, Netherlands
    • Landmesser, Ulf. University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland
    • Wenaweser, Peter. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Meier, Bernhard. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Stefanini, Giulio. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Roffi, Marco. University Hospital, Geneva, Switzerland
    • Lüscher, Thomas. University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland
    • Windecker, Stephan. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    • Räber, Lorenz. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The International Journal of Cardiovascular Imaging, 2015, vol. 31, no. 5, p. 915-926. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332479
    Summary
    We assessed the feasibility and the procedural and long-term safety of intracoronary (i.c) imaging for documentary purposes with optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary PCI in the setting of IBIS-4 study. IBIS4 (NCT00962416) is a prospective cohort study conducted at five European centers including 103 STEMI patients who underwent serial three-vessel coronary imaging during primary PCI and at 13months. The feasibility parameter was successful imaging, defined as the number of pullbacks suitable for analysis. Safety parameters included the frequency of peri-procedural complications, and major adverse cardiac events (MACE), a composite of cardiac death, myocardial infarction (MI) and any clinically-indicated revascularization at 2years. Clinical outcomes were compared with the results from a cohort of 485 STEMI patients undergoing primary PCI without additional imaging. Imaging of the infarct-related artery at baseline (and follow-up) was successful in 92.2% (96.6%) of patients using OCT and in 93.2% (95.5%) using IVUS. Imaging of the non-infarct-related vessels was successful in 88.7% (95.6%) using OCT and in 90.5% (93.3%) using IVUS. Periprocedural complications occurred <2.0% of OCT and none during IVUS. There were no differences throughout 2years between the imaging and control group in terms of MACE (16.7 vs. 13.3%, adjusted HR1.40, 95% CI 0.77-2.52, p=0.27). Multi-modality three-vessel i.c. imaging in STEMI patients undergoing primary PCI is consistent a high degree of success and can be performed safely without impact on cardiovascular events at long-term follow-up.