In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 9, p. 2574-2577
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In: Journal of NeuroVirology, 2015, vol. 21, no. 6, p. 694-701
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In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11
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In: Virus Evolution, 2018, vol. 4, no. 2, p. -
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In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1610-1611
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In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5
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In: Cell, 2016, vol. 166, no. 3, p. 596-608
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...
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In: Cell reports, 2020, vol. 32, no. 9, p. 12 p
Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...
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In: Endocrine, 2020, p. 7 p
The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze...
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In: Journal of Infection, 2020, vol. 81, no. 1, p. 17–47
Breastfeeding is associated with considerable health benefits for infants. Aside from essential nutrients, immune cells and bioactive components, breast milk also contains a diverse range of microbes, which are important for maintaining mammary and infant health. In this review, we summarise studies that have investigated the composition of the breast milk microbiota and factors that might...
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