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Consortium of Swiss Academic Libraries

Depression as a risk factor for acute coronary syndrome: a review

Misteli, Genny ; Stute, Petra

In: Archives of Gynecology and Obstetrics, 2015, vol. 291, no. 6, p. 1213-1220

Université de Fribourg

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Università della Svizzera italiana

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity

Bertelli, Roberta ; Di Donato, Armando ; Cioni, Michela ; Grassi, Fabio ; Ikehata, Masami ; Bonanni, Alice ; Rastaldi, Maria Pia ; Ghiggeri, Gian Marco

In: Plos one, 2014, vol. 9, no. 10, p. e111285

Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...

Università della Svizzera italiana

T regulatory cells are markers of disease activity in multiple sclerosis patients

Dalla Libera, Dacia ; Di Mitri, Diletta ; Bergami, Alessandra ; Centonze, Diego ; Gasperini, Claudio ; Grasso, Maria Grazia ; Galgani, Simona ; Martinelli, Vittorio ; Comi, Giancarlo ; Avolio, Carlo ; Martino, Gianvito ; Borsellino, Giovanna ; Sallusto, Federica ; Battistini,Luca ; Furlan, Roberto

In: Plos one, 2011, vol. 6, no. 6, p. e21386

FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from...