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Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

Pennini, Meghan E. ; De Marco, Anna ; Pelletier, Mark ; Bonnell, Jessica ; Cvitkovic, Romana ; Beltramello, Martina ; Cameroni, Elisabetta ; Bianchi, Siro ; Zatta, Fabrizia ; Zhao, Wei ; Xiao, Xiaodong ; Camara, Maria M. ; DiGiandomenico, Antonio ; Semenova, Elena ; Lanzavecchia, Antonio ; Warrener, Paul ; Suzich, JoAnn ; Wang, Qun ; Corti, Davide ; Stover, C. Kendall

In: Nature communications, 2017, vol. 8, p. 1991

Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resistance. Here, we show the increased prevalence of Klebsiella pneumoniae lipopolysaccharide O2 serotype strains in all...

The oral commensal Streptococcus mitis shows a mixed memory Th cell signature that is similar to and cross-reactive with Streptococcus pneumoniae

Engen, Stian André ; Rukke, Håkon Valen ; Becattini, Simone ; Jarrossay, David ; Blix, Inger Johanne ; Petersen, Fernanda Cristina ; Sallusto, Federica ; Schenck, Karl

In: Plos one, 2017, vol. 9, no. 8, p. e104306

Background: Carriage of and infection with Streptococcus pneumoniae is known to predominantly induce T helper 17 (Th17) responses in humans, but the types of Th cells showing reactivity towards commensal streptococci with low pathogenic potential, such as the oral commensals S. mitis and S. salivarius, remain uncharacterized. Methods: Memory CD4+ T helper (Th) cell subsets were isolated from...

Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies

Salieb-Beugelaar, Georgette B. ; Zhang, Bei ; Nigo, Maurice M. ; Frischmann, Sieghard ; Hunziker, Patrick R.

In: European Journal of Nanomedicine, 2016, vol. 8, no. 3, p. 115-128

Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia

Nickler, Manuela ; Schaffner, Daniela ; Christ-Crain, Mirjam ; Ottiger, Manuel ; Thomann, Robert ; Hoess, Claus ; Henzen, Christoph ; Mueller, Beat ; Schuetz, Philipp

In: Clinical Chemistry and Laboratory Medicine (CCLM), 2016, vol. 54, no. 11, p. 1831-1846

Low specificity of the bacterial index for the diagnosis of bacterial pneumonia by bronchoalveolar lavage

Speich, R. ; Hauser, M. ; Hess, T. ; Wüst, J. ; Grebski, E. ; Kayser, F. ; Russi, E.

In: European Journal of Clinical Microbiology and Infectious Diseases, 1998, vol. 17, no. 2, p. 78-84

Hip Capsule Dimensions in Patients With Femoroacetabular Impingement: A Pilot Study

Weidner, Jan ; Büchler, Lorenz ; Beck, Martin

In: Clinical Orthopaedics and Related Research®, 2012, vol. 470, no. 12, p. 3306-3312

Immuno-detection of Staphylococcus aureus biofilm on a cochlear implant

Kos, M. ; Stenz, L. ; François, P. ; Guyot, J.-P ; Schrenzel, J.

In: Infection, 2009, vol. 37, no. 5, p. 450-454

Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis

Harbarth, S. ; Garbino, J. ; Pugin, J. ; Romand, J. ; Pittet, D.

In: European Journal of Clinical Microbiology and Infectious Diseases, 2005, vol. 24, no. 10, p. 688-690

Influence of age, social patterns and nasopharyngeal carriage on antibodies to three conserved pneumococcal surface proteins (PhtD, PcpA and PrtA) in healthy young children

Hagerman, A. ; Posfay-Barbe, K. ; Grillet, S. ; Ochs, M. ; Brookes, R. ; Greenberg, D. ; Givon-Lavi, N. ; Dagan, R. ; Siegrist, C.-A

In: European Journal of Clinical Microbiology & Infectious Diseases, 2013, vol. 32, no. 1, p. 43-49

Sonication of Removed Breast Implants for Improved Detection of Subclinical Infection

Rieger, U. ; Pierer, G. ; Lüscher, N. ; Trampuz, A.

In: Aesthetic Plastic Surgery, 2009, vol. 33, no. 3, p. 404-408