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Influence of age, social patterns and nasopharyngeal carriage on antibodies to three conserved pneumococcal surface proteins (PhtD, PcpA and PrtA) in healthy young children

Hagerman, A. ; Posfay-Barbe, K. ; Grillet, S. ; Ochs, M. ; Brookes, R. ; Greenberg, D. ; Givon-Lavi, N. ; Dagan, R. ; Siegrist, C.-A

In: European Journal of Clinical Microbiology & Infectious Diseases, 2013, vol. 32, no. 1, p. 43-49

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    Titre
    • Influence of age, social patterns and nasopharyngeal carriage on antibodies to three conserved pneumococcal surface proteins (PhtD, PcpA and PrtA) in healthy young children
    Auteur
    • Hagerman, A.. Department of Child and Adolescent Medicine, University Hospitals of Geneva, 1211, Geneva, Switzerland
    • Posfay-Barbe, K.. Department of Child and Adolescent Medicine, University Hospitals of Geneva, 1211, Geneva, Switzerland
    • Grillet, S.. Department of Pathology-Immunology, University of Geneva, 1211, Geneva, Switzerland
    • Ochs, M.. sanofi pasteur, 69280, Marcy l'Etoile, France
    • Brookes, R.. sanofi pasteur, M2R 3T4, Toronto, Ontario, Canada
    • Greenberg, D.. The Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel
    • Givon-Lavi, N.. The Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel
    • Dagan, R.. The Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel
    • Siegrist, C.-A. Department of Child and Adolescent Medicine, University Hospitals of Geneva, 1211, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Clinical Microbiology & Infectious Diseases, 2013, vol. 32, no. 1, p. 43-49. Springer-Verlag
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:314364
    Summary
    The acquisition of specific antibodies is paramount to protect children against pneumococcal diseases, and a better understanding of how age, ethnicity and/or Streptococcus pneumoniae (Spn) nasopharyngeal carriage influence the acquisition of antibodies to pneumococcal surface proteins (PSP) is important for the development of novel serodiagnostic and immunisation strategies. IgG antibody titres against three conserved PSP (PhtD, PcpA and PrtA) in the sera of 451 healthy children aged 1 to 24months from Israel [Jewish (50.1%) and Bedouin (49.9%)] were measured by enzyme-linked immunosorbent assay (ELISA), while nasopharyngeal swabs from these children were assessed for the presence of Spn. Globally, anti-PhtD and anti-PrtA geometric mean concentrations (GMC; EU/ml) were high at <2.5months of age [PhtD: 35.3, 95% confidence interval (CI) 30.6-40.6; PrtA: 71.2, 95 % CI 60-84.5], was lower at 5-7months of age (PhtD: 10, 95 % CI 8-12.4; PrtA: 17.9, 95 % CI 14.4-22.1) and only increased after 11months of age. In contrast, an increase in anti-PcpA was observed at 5-7months of age. Anti-PcpA and anti-PrtA, but not anti-PhtD, were significantly higher in Bedouin children (PcpA: 361.6 vs. 226.3, p = 0.02; PrtA: 67.2 vs. 29.5, p < 0.001) in whom Spn nasopharyngeal carriage was identified earlier (60% vs. 38% of carriers <6months of age, p = 0.002). Spn carriage was associated with significantly higher anti-PSP concentrations in carriers than in non-carriers (p < 0.001 for each PSP). Thus, age, ethnicity and, essentially, nasopharyngeal carriage exert distinct cumulative influences on infant responses to PSP. These specific characteristics are worthwhile to include in the evaluation of pneumococcal seroresponses and the development of new PSP-based vaccines