In: Interactive CardioVascular and Thoracic Surgery, 2016, vol. 22, no. 4, p. 402-405
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In: Interactive Cardiovascular and Thoracic Surgery, ///-
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In: Clinical & Experimental Metastasis, 2015, vol. 32, no. 7, p. 677-687
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In: Interactive CardioVascular and Thoracic Surgery, 2018, vol. 26, no. 6, p. 977-984
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In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2793-2808
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In: Frontiers in Immunology, 2020, vol. 11, p. -
The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing their function, represents an additional level of regulation on their cognate receptors. In particular, the multi-faceted activity of the...
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In: Scientific Reports, 2020, vol. 10, no. 1, p. 11551
Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. Here, we assessed ventricular restoration after two, three and six cryoinjuries interspaced by recovery periods. Using transgenic cell-lineage tracing analysis, we demonstrated...
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In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -
Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...
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In: Plos one, 2013, vol. 8, no. 9, p. e74045
More effective treatment of metastasizing osteosarcoma with a current mean 5-year survival rate of less than 20% requires more detailed knowledge on mechanisms and key regulatory molecules of the complex metastatic process. CXCR4, the receptor of the chemokine CXCL12, has been reported to promote tumor progression and metastasis in osteosarcoma. CXCR7 is a recently deorphanized...
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In: npj Regenerative Medicine, 2019, vol. 4, no. 1, p. 2
Unlike mammals, adult zebrafish can regenerate their hearts after injury via proliferation of cardiomyocytes. The cell-cycle entry of zebrafish cardiac cells can also be stimulated through preconditioning by thoracotomy, a chest incision without myocardial damage. To identify effector genes of heart preconditioning, we performed transcriptome analysis of ventricles from thoracotomized...
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