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Université de Fribourg

Circadian and genetic modulation of visually-guided navigation in Drosophila larvae

Asirim, Ece Z. ; Humberg, Tim-Henning ; Maier, G. Larisa ; Sprecher, Simon G.

In: Scientific Reports, 2020, vol. 10, no. 1, p. 2752

Organisms possess an endogenous molecular clock which enables them to adapt to environmental rhythms and to synchronize their metabolism and behavior accordingly. Circadian rhythms govern daily oscillations in numerous physiological processes, and the underlying molecular components have been extensively described from fruit flies to mammals. Drosophila larvae have relatively simple nervous...

Università della Svizzera italiana

Protein environment : a crucial triggering factor in Josephin domain aggregation : the role of 2,2,2-trifluoroethanol

Visentin, Cristina ; Navarro, Susanna ; Grasso, Gianvito ; Regonesi, Maria Elena ; Deriu, Marco Agostino ; Tortora, Paolo ; Ventura, Salvador

In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151

The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...

Université de Fribourg

Host range and Specificity of the Drosophila C Virus

Kapun, Martin ; Nolte, Viola ; Flatt, Thomas ; Schlötterer, Christian

In: PLoS ONE, 2010, vol. 5, no. 8, p. 1-5

Background: The Drosophila C virus (DCV) is a common and well-studied Drosophila pathogen. Although natural infections are known from Drosophila melanogaster and D. simulans, and artificial infections have been reported from several. Drosophila species and other insects, it remains unclear to date whether DCV infections also occur naturally in other Drosophila species. Methods/Principal Findings:...

Consortium of Swiss Academic Libraries

Long-range silencing and position effects at telomeres and centromeres: parallels and differences

Perrod, S. ; Gasser, S.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2303-2318