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Sumoylation and transcription regulation at nuclear pores

Texari, Lorane ; Stutz, Françoise

In: Chromosoma, 2015, vol. 124, no. 1, p. 45-56

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    Titre
    • Sumoylation and transcription regulation at nuclear pores
    Auteur
    • Texari, Lorane. Department of Cell Biology, iGE3, University of Geneva, Geneva, Switzerland
    • Stutz, Françoise. Department of Cell Biology, iGE3, University of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:331561
    Summary
    Increasing evidence indicates that besides promoters, enhancers, and epigenetic modifications, nuclear organization is another parameter contributing to optimal control of gene expression. Although differences between species exist, the influence of gene positioning on expression seems to be a conserved feature from yeast to Drosophila and mammals. The nuclear periphery is one of the nuclear compartments implicated in gene regulation. It consists of the nuclear envelope (NE) and the nuclear pore complexes (NPC), which have distinct roles in the control of gene expression. The NPC has recently been shown to tether proteins involved in the sumoylation pathway. Here, we will focus on the importance of gene positioning and NPC-linked sumoylation/desumoylationin transcription regulation. We will mainly discuss observations made in the yeast Saccharomyces cerevisiae model system and highlight potential parallels in metazoan species.