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Université de Fribourg

Towards deciphering variations of heart regeneration in fish

Jaźwińska, Anna ; Blanchoud, Simon

In: Current Opinion in Physiology, 2020, vol. 14, p. 21–26

Among adult vertebrates, the zebrafish presents the rather exceptional capacity to efficiently regenerate its heart after injury. This bony fish has thus become a leading genetic model organism to elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical significance, parallel analyses between zebrafish and mammals are aiming at the identification of...

Université de Fribourg

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

Stolp, Bettina ; Thelen, Flavian ; Ficht, Xenia ; Altenburger, Lukas M. ; Ruef, Nora ; Inavalli, V. V. G. Krishna ; Germann, Philipp ; Page, Nicolas ; Moalli, Federica ; Raimondi, Andrea ; Keyser, Kirsten A. ; Jafari, S. Morteza Seyed ; Barone, Francesca ; Dettmer, Matthias S. ; Merkler, Doron ; Iannacone, Matteo ; Sharpe, James ; Schlapbach, Christoph ; Fackler, Oliver T. ; Nägerl, U. Valentin ; Stein, Jens V.

In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371

It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...

Université de Fribourg

Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth

Savić, Nada D. ; Vojnovic, Sandra ; Glišić, Biljana Đ. ; Crochet, Aurélien ; Pavic, Aleksandar ; Janjić, Goran V. ; Pekmezović, Marina ; Opsenica, Igor M. ; Fromm, Katharina M. ; Nikodinovic-Runic, Jasmina ; Djuran, Miloš I.

In: European Journal of Medicinal Chemistry, 2018, vol. 156, p. 760–773

Mononuclear silver(I) complexes with 1,7-phenanthroline (1,7-phen), [Ag(NO3-O,O′) (1,7-phen-N7)2] (1) and [Ag(1,7-phen-N7)2]X, X = ClO4− (2), CF3SO3− (3), BF4− (4) and SbF6− (5) were synthesized and structurally characterized by NMR (1H and 13C), IR and UV–Vis spectroscopy and ESI mass spectrometry. The crystal structures of 1, 3 and 4 were determined by single-crystal X-ray...