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Université de Fribourg

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Haute Ecole de Santé de Fribourg

Quelle est l'expérience vécue par les patients en attente d'une transplantation rénale ? : une revue de littérature étoffée

Ribi, Amandine ; Zanone, Margaux ; Délétroz, Carole (Dir.)

Mémoire de bachelor : Haute Ecole de Santé de Fribourg, 2014.

Introduction : Les écrits démontrent une réelle complexité liée aux différents enjeux qui se répercutent sur la vie des patients en attente d’une transplantation rénale. La question de recherche qui se pose est : Quelle est l’expérience vécue par les patients en attente d’une transplantation rénale ? Ce travail vise alors à connaître et préciser cette expérience. Méthode :...

Université de Fribourg

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...

Università della Svizzera italiana

Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation

Bernasconi, Riccardo ; Soldà, Tatiana ; Galli, Carmela ; Pertel, Thomas ; Luban, Jeremy ; Molinari, Maurizio

In: Plos one, 2010, vol. 5, no. 9, p. e13008

Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments. Surprisingly, however, no data is available on the involvement of endoplasmic reticulum (ER)-resident members of the PPI family in protein folding, quality control or...