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N -methyl pyrrolidone (NMP) inhibits lipopolysaccharide-induced inflammation by suppressing NF-κB signaling

Ghayor, Chafik ; Gjoksi, Bebeka ; Siegenthaler, Barbara ; Weber, Franz

In: Inflammation Research, 2015, vol. 64, no. 7, p. 527-536

FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

Endothelial nitric oxide synthase in the microcirculation

Shu, Xiaohong ; Keller IV, T. ; Begandt, Daniela ; Butcher, Joshua ; Biwer, Lauren ; Keller, Alexander ; Columbus, Linda ; Isakson, Brant

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 23, p. 4561-4575

Role of connexins and pannexins in cardiovascular physiology

Meens, Merlijn ; Kwak, Brenda ; Duffy, Heather

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2779-2792

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

Zuhra, Karim ; Augsburger, Fiona ; Majtan, Tomas ; Szabo, Csaba

In: Biomolecules, 2020, vol. 10, no. 5, p. 697

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with...

Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase type II and mitochondrial oxidative stress

Liang, Xiujie ; Arullampalam, Prakash ; Yang, Zhihong ; Ming, Xiu-Fen

In: Frontiers in Physiology, 2019, vol. 10, p. -

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Panagaki, Theodora ; Randi, Elisa B. ; Augsburger, Fiona ; Szabo, Csaba

In: Proceedings of the National Academy of Sciences, 2019, p. 201911895

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...

MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

In: Cells, 2019, vol. 8, no. 5, p. 388

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

Temperature measurements in sooting counterflow diffusion flames using laser-induced fluorescence of flame-produced nitric oxide

Denisov, A. ; Colmegna, G. ; Jansohn, P.

In: Applied Physics B, 2014, vol. 116, no. 2, p. 339-346

Lymphatic vessels: new targets for the treatment of inflammatory diseases

Dieterich, Lothar ; Seidel, Catharina ; Detmar, Michael

In: Angiogenesis, 2014, vol. 17, no. 2, p. 359-371