In: Cells, 2020, vol. 9, no. 7, p. 1695
The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...
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In: Cells, 2019, vol. 8, no. 5, p. 388
Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...
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In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15
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In: Political Behavior, 2014, vol. 36, no. 1, p. 125-142
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In: Journal of Inherited Metabolic Disease, 2014, vol. 37, no. 5, p. 831-840
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In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116
The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...
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In: BMC Ophthalmology, 2018, vol. 18, no. 1, p. 149
In 2013 five polar explorers attempted to complete the first Trans-Antarctic Winter Traverse (TAWT). This study presents the ophthalmological findings for this group, who overwintered in Antarctica as part of the White Mars Human Science Protocol. Antarctic crews are exposed to extreme cold, chronic hypoxia and altered day-night cycles. Previous studies of Antarctic explorers have focused on...
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In: Herz Kardiovaskuläre Erkrankungen, 2007, vol. 32, no. 7, p. 568-572
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In: European Archives of Oto-Rhino-Laryngology, 2013, vol. 270, no. 5, p. 1729-1735
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In: Applied Magnetic Resonance, 2012, vol. 43, no. 1-2, p. 275-288
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