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Université de Fribourg

Inhibition of p38mapk reduces adipose tissue inflammation in aging mediated by arginase-II

Huang, Ji ; Liu, Chang ; Ming, Xiu-Fen ; Yang, Zhihong

In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504

Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....

Consortium of Swiss Academic Libraries

A novel animal model for external anal sphincter insufficiency

Brügger, Lukas ; Inglin, Roman ; Candinas, Daniel ; Sulser, Tullio ; Eberli, Daniel

In: International Journal of Colorectal Disease, 2014, vol. 29, no. 11, p. 1385-1392

Université de Fribourg

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, Robert ; Mellows, Ben ; Sheard, Jonathan ; Antonioli, Manuela ; Kretz, Oliver ; Chambers, David ; Zeuner, Marie-Theres ; Tomkins, James E. ; Denecke, Bernd ; Musante, Luca ; Joch, Barbara ; Debacq-Chainiaux, Florence ; Holthofer, Harry ; Ray, Steve ; Huber, Tobias B. ; Dengjel, Jörn ; De Coppi, Paolo ; Widera, Darius ; Patel, Ketan

In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116

The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...

Université de Fribourg

Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe

Contreras, Esteban G. ; Egger, Boris ; Gold, Katrina S. ; Brand, Andrea H.

In: Neural Development, 2018, vol. 13, no. 1, p. 25

Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial...