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Preclinical evaluation and test-retest studies of [18F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5)

Sephton, Selena ; Herde, Adrienne ; Mu, Linjing ; Keller, Claudia ; Rüdisühli, Sonja ; Auberson, Yves ; Schibli, Roger ; Krämer, Stefanie ; Ametamey, Simon

In: European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 1, p. 128-137

Control of Glutamate Transport by Extracellular Potassium: Basis for a Negative Feedback on Synaptic Transmission

Rimmele, Theresa S. ; Rocher, Anne-Bérengère ; Wellbourne-Wood, Joel ; Chatton, Jean-Yves

In: Cerebral Cortex, 2017, vol. 27, no. 6, p. 3272-3283

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

Grimaldi, Mariagrazia ; Karaca, Melis ; Latini, Livia ; Brioudes, Estelle ; Schalch, Thomas ; Maechler, Pierre

In: Human Molecular Genetics, 2017, vol. 26, no. 18, p. 3453-3465

Normobaric Hyperoxia is Associated with Increased Cerebral Excitotoxicity After Severe Traumatic Brain Injury

Quintard, Hervé ; Patet, Camille ; Suys, Tamarah ; Marques-Vidal, Pedro ; Oddo, Mauro

In: Neurocritical Care, 2015, vol. 22, no. 2, p. 243-250

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Bardelli, Marco ; Frontzek, Karl ; Simonelli, Luca ; Hornemann, Simone ; Pedotti, Mattia ; Mazzola, Federica ; Carta, Manfredi ; Eckhardt, Valeria ; D’Antuono, Rocco ; Virgilio, Tommaso ; González, Santiago F. ; Aguzzi, Adriano ; Varani, Luca

In: Plos pathogens, 2018, vol. 14, no. 10, p. e1007335

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective...

The neurobiological link between OCD and ADHD

Brem, Silvia ; Grünblatt, Edna ; Drechsler, Renate ; Riederer, Peter ; Walitza, Susanne

In: ADHD Attention Deficit and Hyperactivity Disorders, 2014, vol. 6, no. 3, p. 175-202

The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice

Singer, Philipp ; Feldon, Joram ; Yee, Benjamin

In: Psychopharmacology, 2009, vol. 202, no. 1-3, p. 371-384

Glycine-induced neurotoxicity in organotypic hippocampal slice cultures

Barth, A. ; Nguyen, L. ; Barth, L. ; Newell, D.

In: Experimental Brain Research, 2005, vol. 161, no. 3, p. 351-357

Hemispheric lateralization of the corticostriatal glutamatergic system in the rat

Capper-Loup, Christine ; Rebell, Dominik ; Kaelin-Lang, Alain

In: Journal of Neural Transmission, 2009, vol. 116, no. 9, p. 1053-1057

Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons

Schaub, Christina ; Uebachs, Mischa ; Beck, Heinz ; Linnebank, Michael

In: Experimental Brain Research, 2013, vol. 225, no. 4, p. 527-534